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トピック - 【レビュー】The immunotherapy era of myeloma: monoclonal antibodies, vaccines and adoptive T cell therapies.

書誌情報:Hoyos V, Borrello I.  2016 Sep 29;128(13):1679-87. Pubmed

カテゴリー:レビュー


Abstract:
The treatment of multiple myeloma has evolved significantly over the last decades from primarily alkylator-based chemotherapeutic agents with minimal efficacy to the introduction of more effective agents including immune modulators and proteasome inhibitors, which have changed the landscape of therapy for this disease. We are now entering a new era that will increasingly integrateimmunotherapy into standard treatment. This review discusses the current immune-based strategies currently approved, as well as various immune approaches being actively investigated including monoclonal antibodies, checkpoint inhibitors, vaccines, and adoptiveT-cell therapies.

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